160850-59-9

Upstream product

• 20357-25-9 6-nitroveratraldehyde 
• 136297-35-3 (2-[¹⁸F]fluoro-4,5-dimethoxyphenyl)methanol 
• 129841-06-1 2-[¹⁸F]fluoro-4,5-dimethoxybenzaldehyde 

Downstream Products

• 491862-95-4 C₂₈H₃₀⁽¹⁸⁾FNO₄ 
• 92812-82-3 [18F]-L-3,4-dihydroxy-6-fluorophenylalanine 

Relevant academic research and scientific papers

Method for preparing [18F]Fluoro-L-Dopa with high radiochemical and enantiomeric purity

The present invention relates to a manufacturing method and a purifying method of [^18f] fluoro-L-dopa with high purity and high specific radioactivity, which is automatically manufactured wherein the [^18f] fluoro-L-dopa requires at least one solution process in each manufacturing step and accordingly has good reproducibility and stable yield, thereby being used in an auto-manufacturing apparatus, and is purified by using a high performance liquid chromatography which uses a solid phase extraction method and chiral column, thereby having good high purity and high specific radioactivity.

Automated production at the curie level of no-carrier-added 6-[18F]fluoro- l -dopa and 2-[18F]fluoro- l -tyrosine on a FASTlab synthesizer

An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[18F]fluoro-L-dopa ([18F]FDOPA) and 2-[18F]fluoro-L-tyrosine ([18F]FTYR) on a GE FASTlab synthesizer in conjunctio

Fast and reliable method for the preparation of ortho- and para-[ 18F]fluorobenzyl halide derivatives: Key intermediates for the preparation of no-carrier-added PET aromatic radiopharmaceuticals

A fast and reliable method suitable for the automated preparation of (substituted) [18F]fluorobenzyl halides from several [ 18F]fluorobenzaldehydes was developed. Aromatic nucleophilic substitution of trimethylammonium benzaldehyde t

Highly enantioselective synthesis of no-carrier-added 6-[ 18F]fluoro-L-dopa by chiral phase-transfer alkylation

[18F]Fluoro-L-dopa, an important radiopharmaceutical for positron emission tomography (PET), has been synthesized using a phase-transfer alkylation reaction. A chiral quaternary ammonium salt derived from a Cinchona alkaloid served as phase-tra

An improved enantioselective synthesis of no-carrier-added (NCA) 6-[18F]fluoro-L-DOPA

6-[18F]Fluoro-L-Dopa (6-FDOPA) is the analogue of L-Dopa, the biosynthesis precursor for dopamine. As a PET tracer, it was widely applied for the presynaptic dopamine function in cerebral studies in humans. The synthesis routes to this radiopharmaceutical could be divided into two main groups, that is, electrophilic and nucleophilic route. Lemaire et al reported a new nucleophilic synthesis procedure using a chiral phase-transfer catalyst. A similar procedure with some improvements was described in this study. A trimethylammonium veratraldehyde triflate was sythesized and used as a precurser for the synthesis of 6-[18F]Fluoro-L-Dopa by using the chiral phase-transfer catalyst, O-Allyl-N-(9)-anthracenylcinchonidium Bromide which was also synthesized in this study. The nca Fluorine-18F-fluoride was produced by the 18O(p,n)18F nuclear reaction on enriched water. First the 6-[19F]Fluoro-L-Dopa was sythesized to test the chemical structure of the sythesized end product and whole procedure. Then the synthesis of 6-[18F]Fluoro-L-Dopa was completed and identified by HPLC,TLC and MS (only the case of the 6-[19F]Fluoro-L-Dopa).