136309-07-4 Usage
General Description
6-Methoxy-pyrazine-2-carbonitrile is a chemical compound with the molecular formula C6H5N3O and a molecular weight of 135.12 g/mol. It is a derivative of pyrazine, a six-membered heterocyclic compound containing two nitrogen atoms in the ring. The presence of a methoxy group and a cyano group in the molecule gives it unique properties and potential applications in pharmaceutical and agrochemical industries. The compound is commonly used as a building block in the synthesis of various organic compounds, and its specific chemical structure makes it suitable for the production of specialized pharmaceuticals and pesticides. Additionally, 6-Methoxy-pyrazine-2-carbonitrile may also have potential applications in the development of new materials and chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 136309-07-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,3,0 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 136309-07:
(8*1)+(7*3)+(6*6)+(5*3)+(4*0)+(3*9)+(2*0)+(1*7)=114
114 % 10 = 4
So 136309-07-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H5N3O/c1-10-6-4-8-3-5(2-7)9-6/h3-4H,1H3
136309-07-4Relevant articles and documents
Studies on Pyrazines. Part 22. Lewis Acid-Mediated Cyanation of Pyrazine N-Oxides with Trimethylsilyl Cyanide: New Route to 2-Substituted 3-Cyanopyrazines
Sato, Nobuhiro,Shimomura, Yuji,Ohwaki, Yoshie,Takeuchi, Ryo
, p. 2877 - 2882 (2007/10/02)
Reaction of 3-substituted pyrazine 1-oxides with trimethylsilyl cyanide in the presence of triethylamine in acetonitrile gave the corresponding cyanopyrazines, yields of which depended remarkably on the substituent.Electron-donating groups enhanced the cyanation with high regioselectivity to 2-substituted 3-cyanopyrazines, while a chloro substituent suppressed the conversion.Addition of zinc halide to the reaction mixture, in most cases, increased the reactivity and improved the regioselectivity.On the other hand, the N-oxides carrying an electron-withdrawing methoxycarbonyl or N-butylcarbamoyl group underwent the cyanation, without need for the Lewis acid, to provide a mixture of nearly equal amounts of 2-substituted 3- and 5-cyanopyrazines.The latter compound was exclusively obtained when 3-methoxycarbonyl- or 3-cyanopyrazine 1-oxide was treated with diethoxyphosphoryl cyanide.
