136322-58-2

Upstream product

• 94265-72-2 1-(p-Tolylsulfonyl)-4-(p-tolylsulfonyloxy)-butan 
• 136495-34-6 (R)-4-Phenyl-3-[4-(toluene-4-sulfonyl)-butyl]-oxazolidine 
• 56613-80-0 D-2-phenylglycinol 
• 136495-45-9 1,1,1-Trifluoro-6-((R)-4-phenyl-oxazolidin-3-yl)-3-(toluene-4-sulfonyl)-2-trifluoromethyl-hexan-2-ol 

Downstream Products

• 136495-25-5 1,1,1,3,3,3-Hexafluoro-2-[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-yl]-propan-2-ol 
• 136322-59-3 1,1,1,3,3,3-Hexafluoro-2-[(R)-1-((R)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-yl]-propan-2-ol 

Relevant academic research and scientific papers

Synthesis of 2-Bis(trifluoromethyl)hydroxymethyl Substituted Cyclic Amines through Novel Intramolecular Substitution of an Arylsulfonyl Group

ω-Amino-1,1-bis(trifluoromethyl)-2-sulfonyl-1-pentanol or -hexanol provided the corresponding pyrrolidine or piperidine having BTHM group at the 2-position via intermediary epoxide by treating with NaOH in the presence of phase-transfer catalyst.