1363300-70-2Relevant academic research and scientific papers
The Staudinger/aza-Wittig/Grignard reaction as key step for the concise synthesis of 1-C-Alkyl-iminoalditol glycomimetics
Zoidl, Manuel,Gonzalez Santana, Andres,Torvisco, Ana,Tysoe, Christina,Siriwardena, Aloysius,Withers, Stephen G.,Wrodnigg, Tanja M.
, p. 62 - 70 (2016)
The scope of a one-pot tandem approach for the synthesis of C-1 alkyl iminoalditol derivatives with a Staudinger/aza-Wittig/Grignard cascade has been evaluated. The reaction conditions have been optimized for two azidodeoxy aldose substrates and a range o
β-GLUCOCEREBROSIDASE CHAPERONES
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, (2013/06/06)
The present application relates to compounds of the Formula (I): which are useful or the treatment of diseases in which the wild type or a mutant form of the enzyme β-glucocerebrosidase is implicated.
Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease
Goddard-Borger, Ethan D.,Tropak, Michael B.,Yonekawa, Sayuri,Tysoe, Christina,Mahuran, Don J.,Withers, Stephen G.
supporting information; experimental part, p. 2737 - 2745 (2012/06/01)
A highly divergent route to lipophilic iminosugars that utilizes the thiol-ene reaction was developed to enable the rapid synthesis of a collection of 16 dideoxyiminoxylitols bearing various different lipophilic substituents. Enzyme kinetic analyses revea
