1363300-97-3

Upstream product

• 1363300-67-7 (2R,3S,4S,5R)-3,4,5-tris(benzyloxy)-2-vinyl-piperidine 
• 1363300-56-4 (2R,3S,4S,5R)-3,4,5-trihydroxy-2-vinyl-piperidine hydrochloride 
• 5157-51-7 1-(2-mercaptoethyl)-3-phenyl-urea 

Relevant academic research and scientific papers

β-GLUCOCEREBROSIDASE CHAPERONES

The present application relates to compounds of the Formula (I): which are useful or the treatment of diseases in which the wild type or a mutant form of the enzyme β-glucocerebrosidase is implicated.

Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease

A highly divergent route to lipophilic iminosugars that utilizes the thiol-ene reaction was developed to enable the rapid synthesis of a collection of 16 dideoxyiminoxylitols bearing various different lipophilic substituents. Enzyme kinetic analyses revea