5157-51-7

Usage

Functional groups

Phenyl group, urea functional group, sulfanyl ethyl group specific parts of the molecule that give the compound its characteristic chemical properties.

Synthesis

Reaction of phenethylamine with carbon disulfide and chloroform, followed by treatment with ammonia a description of the process used to create the compound in a laboratory setting.

Inhibition of enzyme activity

Urease the specific enzyme that 1-phenyl-3-(2-sulfanylethyl)urea inhibits, playing a role in the metabolism of nitrogen-containing compounds in living organisms.

Upstream product

• 14033-42-2 bis-[2-(3-phenylureido)ethyl]disulfide 
• 62-53-3 aniline 
• 56-17-7 cystamine dihydrochioride 
• 103-71-9 phenyl isocyanate 
• 93311-82-1 NSC 207837 
• 95028-25-4 1-<2-Methylmercaptocarbonylmercapto-ethyl>-3-phenyl-harnstoff 

Downstream Products

• 1363300-97-3 (2R,3S,4S,5R)-3,4,5-trihydroxy-2-{2-[2-(phenylaminocarbonyl)amino-ethylsulfanyl]-ethyl}-piperidine hydrochloride 

Relevant academic research and scientific papers

β-GLUCOCEREBROSIDASE CHAPERONES

The present application relates to compounds of the Formula (I): which are useful or the treatment of diseases in which the wild type or a mutant form of the enzyme β-glucocerebrosidase is implicated.

Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease

A highly divergent route to lipophilic iminosugars that utilizes the thiol-ene reaction was developed to enable the rapid synthesis of a collection of 16 dideoxyiminoxylitols bearing various different lipophilic substituents. Enzyme kinetic analyses revea

A di-palladium urea complex as a molecular receptor for anions

A new di-nuclear palladium complex containing thiol-urea ligands has been prepared, structurally characterized and its interaction with anionic species studied in solution. The Royal Society of Chemistry 2005.