1363339-37-0Relevant academic research and scientific papers
Total synthesis of sinenside a
Vadhadiya, Paresh M.,Ramana, Chepuri V.
, p. 1724 - 1727 (2015)
The first total synthesis of norlignan glucoside sinenside A has been accomplished. An intramolecular acetalization reaction has been employed as the key skeletal construct to forge the central cyclic disaccharide core. The trans-1,2-diol configuration present in the cyclic disaccharide of this natural product is unique and has been addressed by setting this configuration at the beginning. A 1,2-orthoester group has been selected as a handle for both sp glycosidation and for differentiation of the C2′-OH (that participates in the key acetalization reaction) of the sugar unit.
