1363401-51-7Relevant articles and documents
Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists
Guo, Chuangxing,Pairish, Mason,Linton, Angelica,Kephart, Susan,Ornelas, Martha,Nagata, Asako,Burke, Benjamin,Dong, Liming,Engebretsen, Jon,Fanjul, Andrea N.
, p. 2572 - 2578 (2012/05/05)
Oxobenzimidazoles (e.g., 1), a novel series of androgen receptor (AR) antagonists, were discovered through de novo design guided by structure-based drug design. The compounds in this series were reasonably permeable and metabolically stable, but suffered