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1363402-35-0

2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1363402-35-0 Structure

  • Basic information

    1. Product Name: 2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester
    2. Synonyms:
    3. CAS NO:1363402-35-0
    4. Molecular Formula:
    5. Molecular Weight: 215.249
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1363402-35-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester(1363402-35-0)
    11. EPA Substance Registry System: 2-methylazetidine-1,2-dicarboxylic acid 1-tert-butyl ester(1363402-35-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1363402-35-0(Hazardous Substances Data)

1363402-35-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1363402-35-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,3,4,0 and 2 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1363402-35:
(9*1)+(8*3)+(7*6)+(6*3)+(5*4)+(4*0)+(3*2)+(2*3)+(1*5)=130
130 % 10 = 0
So 1363402-35-0 is a valid CAS Registry Number.

1363402-35-0Downstream Products

1363402-35-0Relevant articles and documents

Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: From hit to clinic

Pizzonero, Mathieu,Dupont, Sonia,Babel, Marielle,Beaumont, Stéphane,Bienvenu, Natacha,Blanqué, Roland,Cherel, La?titia,Christophe, Thierry,Crescenzi, Benedetta,De Lemos, Elsa,Delerive, Philippe,Deprez, Pierre,De Vos, Steve,Djata, Fatoumata,Fletcher, Stephen,Kopiejewski, Sabrina,Lebraly, Christelle,Lefran?ois, Jean-Michel,Lavazais, Stéphanie,Manioc, Murielle,Nelles, Luc,Oste, Line,Polancec, Denis,Quénéhen, Vanessa,Soulas, Florilène,Triballeau, Nicolas,Van Der Aar, Ellen M.,Vandeghinste, Nick,Wakselman, Emanuelle,Brys, Reginald,Saniere, Laurent

, p. 10044 - 10057 (2015/02/05)

FFA2, also called GPR43, is a G-protein coupled receptor for short chain fatty acids which is involved in the mediation of inflammatory responses. A class of azetidines was developed as potent FFA2 antagonists. Multiparametric optimization of early hits with moderate potency and suboptimal ADME properties led to the identification of several compounds with nanomolar potency on the receptor combined with excellent pharmacokinetic (PK) parameters. The most advanced compound, 4-[[(R)-1-(benzo[b]thiophene-3-carbonyl)-2-methyl-azetidine-2-carbonyl]-(3-chloro-benzyl)-amino]-butyric acid 99 (GLPG0974), is able to inhibit acetate-induced neutrophil migration strongly in vitro and demonstrated ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay. All together, these data supported the progression of 99 toward next phases, becoming the first FFA2 antagonist to reach the clinic.

Practical preparation of enantiopure 2-methyl-azetidine-2-carboxylic acid; a γ-turn promoter

Drouillat, Bruno,Wright, Karen,Marrot, Jerome,Couty, Francois

, p. 690 - 696 (2012/09/21)

A robust and practical synthesis of each enantiomer of 2-methyl-azetidine- 2-carboxylic acid, based on the use of (S)-phenylglycinol as resolving agent, is described. This synthesis affords practical quantities of this quaternary amino acid suitably N- an

AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES

-

, (2012/08/07)

Compounds are disclosed that have a formula represented by the following: These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example inflammatory conditions, infectious diseases, autoimmune diseases, diseases involving impairment of immune cell functions, cardiometabolic diseases, and/or proliferative diseases.

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