449758-77-4 Usage
Description
2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester is a chemical compound characterized by its unique four-membered azetidine ring and ester functionality. It is synthesized from 2-methyl-1,2-azetidinedicarboxylic acid and 1-(1,1-dimethylethyl) alcohol, and is known for its high reactivity, making it a valuable building block in the pharmaceutical industry for the synthesis of various drugs.
Uses
Used in Pharmaceutical Industry:
2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester is used as a building block for the synthesis of various drugs due to its ability to introduce the azetidine ring into complex molecules, which can enhance the biological activity and pharmacological properties of the resulting compounds.
Used in Organic Synthesis:
As a highly reactive reagent, 2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester is employed in organic synthesis to introduce the azetidine ring into target molecules, facilitating the development of new chemical entities with potential applications in various fields.
Used in Agrochemical Production:
2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester is utilized in the production of agrochemicals, where its reactivity and ability to form stable azetidine-containing compounds contribute to the development of effective and targeted crop protection products.
Used in Specialty Chemicals:
2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester is also used in the production of specialty chemicals, where its unique structural features and reactivity can be harnessed to create novel materials with specific properties for various applications.
Safety Considerations:
Due to the reactivity and potential toxicity of 2-Methyl-1,2-azetidinedicarboxylic acid 1-(1,1-dimethylethyl) ester, it is essential to follow proper handling and disposal procedures when working with this compound to ensure the safety of personnel and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 449758-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,9,7,5 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 449758-77:
(8*4)+(7*4)+(6*9)+(5*7)+(4*5)+(3*8)+(2*7)+(1*7)=214
214 % 10 = 4
So 449758-77-4 is a valid CAS Registry Number.
449758-77-4Relevant articles and documents
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: From hit to clinic
Pizzonero, Mathieu,Dupont, Sonia,Babel, Marielle,Beaumont, Stéphane,Bienvenu, Natacha,Blanqué, Roland,Cherel, La?titia,Christophe, Thierry,Crescenzi, Benedetta,De Lemos, Elsa,Delerive, Philippe,Deprez, Pierre,De Vos, Steve,Djata, Fatoumata,Fletcher, Stephen,Kopiejewski, Sabrina,Lebraly, Christelle,Lefran?ois, Jean-Michel,Lavazais, Stéphanie,Manioc, Murielle,Nelles, Luc,Oste, Line,Polancec, Denis,Quénéhen, Vanessa,Soulas, Florilène,Triballeau, Nicolas,Van Der Aar, Ellen M.,Vandeghinste, Nick,Wakselman, Emanuelle,Brys, Reginald,Saniere, Laurent
, p. 10044 - 10057 (2015/02/05)
FFA2, also called GPR43, is a G-protein coupled receptor for short chain fatty acids which is involved in the mediation of inflammatory responses. A class of azetidines was developed as potent FFA2 antagonists. Multiparametric optimization of early hits with moderate potency and suboptimal ADME properties led to the identification of several compounds with nanomolar potency on the receptor combined with excellent pharmacokinetic (PK) parameters. The most advanced compound, 4-[[(R)-1-(benzo[b]thiophene-3-carbonyl)-2-methyl-azetidine-2-carbonyl]-(3-chloro-benzyl)-amino]-butyric acid 99 (GLPG0974), is able to inhibit acetate-induced neutrophil migration strongly in vitro and demonstrated ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay. All together, these data supported the progression of 99 toward next phases, becoming the first FFA2 antagonist to reach the clinic.
Substituted β-alanine derivatives as cell adhesion inhibitors
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, (2008/06/13)
β-Alanine derivatives of Formula I are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.