1363411-71-5

Usage

Type of compound

Fluoro-substituted aniline derivative

Usage

Organic synthesis and pharmaceutical research

Functional groups

Trifluoromethyl group, hex-1-yn-1-yl group

Application

Development of new pharmaceuticals and agrochemicals

Importance

Unique structure and functional groups

Role in synthesis

Building block for complex organic molecules

Utilization

Reagent in chemical reactions for introducing fluorine-containing substituents

Purpose

Drug discovery and development

Upstream product

• 1363411-68-0 2-iodo-3,5,6-trifluoro-4-(trifluoromethyl)aniline 
• 693-02-7 hex-1-yne 
• 123950-43-6 2,3,5-trifluoro-4-(trifluoromethyl)aniline 

Downstream Products

• 1450916-30-9 2-butyl-4,6,7-trifluoro-5-(trifluoromethyl)-indole 

Relevant academic research and scientific papers

The p-toluenesulfonic acid-catalyzed transformation of polyfluorinated 2-alkynylanilines to 2-aminoarylketones and indoles

The reactivity of a series of polyfluorinated 2-alkynylanilines with various alcohols using p-TSA has been studied. It was found that hydration of the triple bond gave rise to polyfluorinated 2-aminoarylketones and competed with an electrophilic heterocyc

Synthesis of indoles with a polyfluorinated benzene ring

A two-step sequence consisting of a Sonogashira coupling of polyfluorinated 2-iodoanilines with terminal alkynes, followed by a KOH promoted cyclization of the 2-alkynylanilines thus formed, has been developed as a one-pot synthesis of 2-R-indoles (R=n-Bu

Synthesis of polyfluorinated ortho-alkynylanilines

A series of polyfluorinated ortho-alkynylanilines - the versatile building blocks for diverse polyfluorobenzo azaheterocycles - have been synthesized by the Sonogashira reaction of polyfluorinated ortho-iodanilines with terminal alkynes.