1363479-11-1

Basic information

• Product Name: (7-(N-(2-hydroxyethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
• Synonyms: (7-(N-(2-hydroxyethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
• CAS NO: 1363479-11-1
• Molecular Weight: 754.796
• Mol File: 1363479-11-1.mol

Chemical Properties

• CAS DataBase Reference: (7-(N-(2-hydroxyethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (7-(N-(2-hydroxyethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate(1363479-11-1)
• EPA Substance Registry System: (7-(N-(2-hydroxyethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate(1363479-11-1)

Safety Data

• Hazardous Substances Data: 1363479-11-1(Hazardous Substances Data)

Upstream product

• 128781-07-7 5,6,7-trimethoxy-1H-indole-2-carboxylic acid 
• 1214876-51-3 2,2,2-trifluoro-1-(1-(iodomethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl)ethan-1-one 
• 1363480-82-3 (7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate 
• 1363480-74-3 N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide 
• 1363480-72-1 N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide 
• 1363480-71-0 (7-(chlorosulfonyl)-5-nitro-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl acetate 
• 1363480-67-4 (7-(chlorosulfonyl)-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl acetate 
• 1363480-64-1 (3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl acetate 
• 1214876-52-4 (3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)-methyl methanesulfonate 
• 885226-91-5 1-(1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone 
• 454713-41-8 tert-butyl 1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 454713-47-4 tert-butyl (1-bromonaphthalen-2-yl)carbamate 

Relevant articles and documents

Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy

The synthesis of 19 (5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl sulfonate prodrugs containing sulfonate leaving groups and 7-substituted electron-withdrawing groups is reported. These were designed to undergo hypoxia-selective metabolism to form potent DNA minor groove-alkylating agents. Analogues 17 and 24, containing the benzyl sulfonate leaving group and a neutral DNA minor groove-binding side chain, displayed hypoxic cytotoxicity ratios (HCRs) of >1000 in HT29 human cancer cells in vitro in an antiproliferative assay. Four analogues maintained large HCRs across a panel of eight human cancer cell lines. In a clonogenic assay, 19 showed an HCR of 4090 in HT29 cells. Ten soluble phosphate preprodrugs were also prepared and evaluated in vivo, alone and in combination with radiation in SiHa human tumor xenografts at a nontoxic dose. Compounds 34 and 39 displayed hypoxic log10 cell kills (LCKs) of 1.78 and 2.71, respectively, equivalent or superior activity to previously reported chloride or bromide analogues, thus showing outstanding promise as hypoxia-activated prodrugs.