1363597-60-7

Upstream product

• 372520-85-9 ethyl 6,6''-bis-(bromomethyl)-2,2':6',2''-terpyridine-4'-carboxylate 
• 1363597-59-4 tetraethyl (4′-bromomethyl-2,2′:6′,2′-terpyridine-6,6′-diyl)bis(methylenenitrilo)tetrakis(acetate) 
• 123-30-8 4-amino-phenol 
• 1363597-57-2 4'-hydroxymethyl-6-6''-bis(bromomethyl)-2,2':6',2''-terpyridine 

Downstream Products

• 1363597-61-8 C₃₂H₃₂N₆O₉ 

Relevant academic research and scientific papers

A ratiometric luminescence probe for highly reactive oxygen species based on lanthanide complexes

Reactive oxygen species (ROS) are important mediators in a variety of pathological events, but the oxidative stress owing to excessive generation of ROS is implicated in many human diseases. In this work, we designed and synthesized a novel dual-functional chelating ligand, [4′-(p-aminophenoxy) methylene-2,2′:6′,2″-terpyridine-6,6″-diyl] bis(methylenenitrilo)tetrakis(acetic acid) (AMTTA), that can strongly coordinate with both Eu3+ and Tb3+ in aqueous solutions for the recognition and time-gated luminescence detection of highly ROS (hROS), hydroxyl radical (?OH), and hypochlorite (ClO-). The complexes AMTTA-Ln3+ (Ln = Eu and Tb) are almost nonluminescent because of the photoinduced electron transfer from the electron-rich aminophenyl group to the terpyridine-Ln3+ moiety but can rapidly react with hROS to afford highly luminescent complexes (4′-hydroxymethyl-2,2′:6′, 2″-terpyridine-6,6″-diyl)bis(methylenenitrilo)tetrakis(acetate) -Ln3+ (HTTA-Ln3+). Interestingly, when the AMTTA-Eu 3+/Tb3+ mixture (AMTTA/Eu3+/Tb3+ = 2/1/1) was reacted with hROS, the intensity ratio of its Tb3+ emission at 540 nm to its Eu3+ emission at 610 nm, I 540/I610, showed a ratiometric response toward hROS, and the dose-dependent increase of the ratio displayed a double-exponential correlation to the concentration of hROS. This unique luminescence response allowed the AMTTA-Eu3+/Tb3+ mixture to be used as a ratiometric probe for the time-gated luminescence detection of hROS.