1363650-13-8Relevant academic research and scientific papers
Synthesis of α,α-diaryl nitriles by radical nucleophilic substitution
Tempesti, Tomas C.,Pierini, Adriana B.,Baumgartner, Maria T.
experimental part, p. 597 - 602 (2012/04/18)
The present study shows that the anion of 2-naphthylacetonitrile is substituted selectively at its Cα by aromatic halides, through a radical nucleophilic substitution mechanism, to give the corresponding α,α-diaryl nitriles in good yields. The regioselectivity of this ambident nucleophile changes with the steric hindrance at the radical centre from the aromatic substrate. The selectivity observed was investigated through a computational model of the key reaction step. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.
