1363683-54-8Relevant academic research and scientific papers
Novel Chiral Bifunctional L-Thiazoline-Thiourea Derivatives: Design and Application in Enantioselective Michael Reactions
Lai, Qi,Li, Yang,Gong, Zhiyong,Liu, Qingwen,Wei, Chiyu,Song, Zhiguang
, p. 979 - 988 (2015)
Several novel chiral bifunctional L-thiazoline-thiourea derivatives were easily synthesized from commercially available L-cysteine in high yield. These catalysts were subsequently applied to the enantioselective Michael addition of acetylacetone to β-nitr
Novel chiral bifunctional L-thiazoline-amide derivatives: Design and application in the direct enantioselective aldol reactions
Gong, Zhiyong,Wei, Chiyu,Shi, Ye,Zheng, Qingchuan,Song, Zhiguang,Liu, Zaiqun
, p. 1827 - 1835 (2014/03/21)
Several novel chiral bifunctional l-thiazoline-amide derivatives were simply synthesized from commercially available l-cysteine and l-proline in high yield. These catalysts were subsequently applied to the direct enantioselective aldol reactions of variou
Novel chiral thiazoline-containing NO ligands in the asymmetric addition of diethylzinc to aldehydes: Substituent effect on the enantioselectivity
Gong, Zhiyong,Liu, Qingwen,Xue, Pengchong,Li, Kechang,Song, Zhiguang,Liu, Zaiqun,Jin, Yinghua
experimental part, p. 121 - 129 (2012/05/05)
Several novel chiral thiazoline primary and tertiary alcohols were easily synthesized from commercially available l-cysteine in three steps and with high yield. These ligands were subsequently applied to the asymmetric addition of diethylzinc (Et2Zn) to various aldehydes. Products with S configuration were obtained when thiazoline-containing tertiary alcohol ligands were used as catalysts. The primary alcohol induced corresponding products with R configuration in 68% enantiomeric excess, which was a higher value relative to other NO ligands possessing a primary alcohol unit in the literature. Furthermore, a plausible transition state model was proposed to explain the observed enantioselectivities. Copyright
