136382-01-9Relevant academic research and scientific papers
SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M
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Paragraph 0086, (2015/04/21)
Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R″, X,
The power of solvent in altering the course of photorearrangements
Sebej, Peter,Lim, Bum Hee,Park, Bong Ser,Givens, Richard S.,Klan, Petr
, p. 644 - 647 (2011/04/15)
A clean bifurcation between two important photochemical reactions through competition of a triplet state Type II H-abstraction reaction with a photo-Favorskii rearrangement for (o/p)-hydroxy-o-methylphenacyl esters that depends on the water content of the solvent has been established. The switch from the anhydrous Type II pathway that yields indanones to the aqueous-dependent pathway producing benzofuranones occurs abruptly at low water concentrations (～8%). The surprisingly clean yields suggest that such reactions are synthetically promising.
Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues
Qui, Xiao-Long,Li, Guideng,Wu, Guikai,Zhu, Jiewen,Zhou, Longen,Chen, Phang-Lang,Chamberlin, A. Richard,Lee, Wen-Hwa
experimental part, p. 1757 - 1767 (2010/02/28)
High expression in cancer 1 (Hec1) is an oncogene overly expressed in many human cancers. Small molecule inhibitor of Nek2/Hec1 (INH) targeting the Hec1 and its regulator, Nek2, in the mitotic pathway, was identified to inactivate Hec1/Nek2 function media
