136382-34-8Relevant academic research and scientific papers
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells
Rodriguez, Veronica,Valente, Sergio,Rovida, Stefano,Rotili, Dante,Stazi, Giulia,Lucidi, Alessia,Ciossani, Giuseppe,Mattevi, Andrea,Botrugno, Oronza A.,Dessanti, Paola,Mercurio, Ciro,Vianello, Paola,Minucci, Saverio,Varasi, Mario,Mai, Antonello
, p. 665 - 670 (2015)
On the basis of previous research showing the capability of N-carbobenzyloxy-(Z-)amino acid-tranylcypromine (-TCPA) derivatives to inhibit LSD1, we inserted at the 4-amino-TCPA moiety first a Z-Pro (9) and a Z-Gly (10) residue and then, after the encouraging data obtained for 9, a pyrrole and an indole ring in which the relative N1 position carried a acetophenone, a N-phenyl/benzylacetamide, or a Z chain (11a-f and 12a-f, respectively). In both series, the Z-pyrrole and indole derivatives 11e, f and 12e, f displayed high LSD1 inhibitory activity. The compounds are able to inhibit LSD1 in NB4 cells, increasing the expression of two related genes, GFI-1b and ITGAM, and to induce cell growth arrest in the AML MB4-11 and APL NB4 cell lines. This journal is
AMIDO ANTI-VIRAL COMPOUNDS
-
Page/Page column 69-70, (2008/12/05)
Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I), their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R3, X, V, W, T, Z, R, Y1, and p are as defined herein.
Aromatic pyrrolidine amide prolyl endopeptidase inhibitors
-
, (2008/06/13)
A series of aromatic pyrrolidine derivatives and suitable pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as PEP inhibitors in the treatment of Alzheimer's disease, amnesia, dementia, anxiety ischemia, or stroke.
