136386-46-4

Basic information

• Product Name: 3-benzyl-5'-O-cinnamoyl-2',3'-O-isopropylidene-5-fluorouridine
• Synonyms: 3-benzyl-5'-O-cinnamoyl-2',3'-O-isopropylidene-5-fluorouridine
• CAS NO: 136386-46-4
• Molecular Weight: 522.53
• Mol File: 136386-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzyl-5'-O-cinnamoyl-2',3'-O-isopropylidene-5-fluorouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-5'-O-cinnamoyl-2',3'-O-isopropylidene-5-fluorouridine(136386-46-4)
• EPA Substance Registry System: 3-benzyl-5'-O-cinnamoyl-2',3'-O-isopropylidene-5-fluorouridine(136386-46-4)

Safety Data

• Hazardous Substances Data: 136386-46-4(Hazardous Substances Data)

Upstream product

• 2797-17-3 2',3'-O-isopropylidene-5-fluorouridine 
• 100-44-7 benzyl chloride 
• 102-92-1 cinnamoyl chloride 
• 136386-45-3 3-benzyl-2',3'-O-isopropylidene-5-fluorouridine 

Downstream Products

• 129141-78-2 (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester 
• 136386-47-5 3-benzyl-5'-O-cinnamoyl-5-fluorouridine 

Relevant articles and documents

A synthesis of 5'-O-acryloyl-5-fluorouridine by use of p-methoxybenzyl group as an N3-imide protecting group of 5-fluorouridine

5'-O-Acryloyl-5-fluorouridine was preparedd by use of p-methoxybenzyl (PMB) group as an N3-imide protecting group of 5-fluorouridine. PMB group was introduced chemoselectively by use of N,N-diisopropylethylamine or DBU as a base. A new deprotection method was developed by means of AlCl3-anisole system at room temperature.