129141-78-2

Basic information

• Product Name: (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
• CAS NO: 129141-78-2
• Molecular Weight: 392.341
• Mol File: 129141-78-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester(129141-78-2)
• EPA Substance Registry System: (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester(129141-78-2)

Safety Data

• Hazardous Substances Data: 129141-78-2(Hazardous Substances Data)

Upstream product

• 129141-69-1 5'-O-Cinnamoyl-2',3'-O-isopropylidene-5-fluorouridine 
• 129141-75-9 (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester 
• 129141-72-6 (E)-3-Phenyl-acrylic acid (3aR,4R,6R,6aR)-6-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 129141-66-8 2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine 
• 2797-17-3 2',3'-O-isopropylidene-5-fluorouridine 
• 136386-47-5 3-benzyl-5'-O-cinnamoyl-5-fluorouridine 
• 129141-75-9 5'-O-cinnamoyl-3-(4-methoxybenzyl)-5-fluorouridine 
• 102-92-1 cinnamoyl chloride 
• 129141-72-6 5'-O-cinnamoyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine 
• 136386-46-4 3-benzyl-5'-O-cinnamoyl-2',3'-O-isopropylidene-5-fluorouridine 
• 136386-45-3 3-benzyl-2',3'-O-isopropylidene-5-fluorouridine 

Relevant articles and documents

A synthesis of 5'-O-acryloyl-5-fluorouridine by use of p-methoxybenzyl group as an N3-imide protecting group of 5-fluorouridine

5'-O-Acryloyl-5-fluorouridine was preparedd by use of p-methoxybenzyl (PMB) group as an N3-imide protecting group of 5-fluorouridine. PMB group was introduced chemoselectively by use of N,N-diisopropylethylamine or DBU as a base. A new deprotection method was developed by means of AlCl3-anisole system at room temperature.

5-Fluorouracil derivatives. XX. Synthesis and antitumor activity of 5'-O-unsaturated acyl-5-fluorouridines

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