136411-21-7

Basic information

• Product Name: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine
• Synonyms: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine;5-bromo-4-(trifluoromethyl)thiazol-2-amine;5-broMo-4-(trifluoroMethyl)-1,3-thiazol-2-aMine;2-ThiazolaMine,5-broMo-4-(trifluoroMethyl)-;5-Bromo-4-trifluoromethyl-thiazol-2-ylamine;5-Bromo-4-(trifluoromethyl)
• CAS NO: 136411-21-7
• Molecular Formula: C₄H₂BrF₃N₂S
• Molecular Weight: 247.0362896
• Mol File: 136411-21-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 272.951 °C at 760 mmHg
• Flash Point: 118.877 °C
• Appearance: /
• Density: 1.99 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.18±0.10(Predicted)
• CAS DataBase Reference: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine(136411-21-7)
• EPA Substance Registry System: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine(136411-21-7)

Safety Data

• Hazardous Substances Data: 136411-21-7(Hazardous Substances Data)

Usage

General Description

5-bromo-4-trifluoromethyl-thiazole-2-ylamine is a chemical compound with the molecular formula C5H3BrF3N3S. It is a thiazole derivative that contains a bromine atom, a trifluoromethyl group, and an amine functional group. 5-bromo-4-trifluoromethyl-thiazole-2-ylamine has potential applications in pharmaceutical and agrochemical industries due to its diverse biological activities. Specifically, it has been studied for its potential as a building block in the synthesis of various pharmaceutical drugs and agrochemical compounds. Additionally, it may have applications in medicinal chemistry, such as in the development of new treatments for various diseases. Its unique structure and properties make it a valuable molecule for further research and development in these fields.

InChI:InChI=1/C4H2BrF3N2S/c5-2-1(4(6,7)8)10-3(9)11-2/h(H2,9,10)

Upstream product

• 349-49-5 4-(trifluoromethyl)-1,3-thiazol-2-amine 

Downstream Products

• 1211525-16-4 5-bromo-4-(trifluoromethyl)thiazole 
• 682342-69-4 N-(5-bromo-4-trifluoromethylthiazol-2-yl)-3,4-dicloro-benzamide 
• 869854-05-7 2-{4-[2-amino-4-(trifluoromethyl)thiazol-5-ylthio]phenyl}-1,1,1-trifluoropropan-2-ol 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

ARYL SULFONES AND USES RELATED THERETO

Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.