1364124-00-4

Upstream product

• 937273-30-8 [2-(2-chloroethoxy)-5-nitrophenyl]methanol 
• 937273-31-9 1-(2-chloroethoxy)-2-((allyloxy)methyl)-4-nitrobenzene 
• 937273-32-0 1-(2-{4-nitro-2-[(prop-2-en-1-yloxy)methyl]phenoxy}ethyl)pyrrolidine 
• 937273-33-1 3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenylamine 
• 1364123-85-2 4-(5-allyloxymethylpyridin-3-yl)-2-chloropyrimidine 
• 859518-11-9 5-(2-chloropyrimidin-4-yl)pyridine-3-carbaldehyde 
• 1364123-81-8 [5-(2-chloropyrimidin-4-yl)pyridin-3-yl]methanol 

Relevant academic research and scientific papers

Discovery of the macrocycle (9 E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25- trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9, 14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of Janus kinase 2/Fms-liketyrosine kinase-3 (J

Herein, we describe the synthesis and SAR of a series of small molecule macrocycles that selectively inhibit JAK2 kinase within the JAK family and FLT3 kinase. Following a multiparameter optimization of a key aryl ring of the previously described SB1518 (