136414-04-5

Basic information

• Product Name: 5-[(2-naphthyloxy)methyl]-1,3,4-oxadiazol-2-yl hydrosulfide
• Synonyms: 5-[(2-naphthyloxy)methyl]-1,3,4-oxadiazol-2-yl hydrosulfide
• CAS NO: 136414-04-5
• Molecular Formula: C₁₃H₁₀N₂O₂S
• Molecular Weight: 258.2957
• Mol File: 136414-04-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-[(2-naphthyloxy)methyl]-1,3,4-oxadiazol-2-yl hydrosulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2-naphthyloxy)methyl]-1,3,4-oxadiazol-2-yl hydrosulfide(136414-04-5)
• EPA Substance Registry System: 5-[(2-naphthyloxy)methyl]-1,3,4-oxadiazol-2-yl hydrosulfide(136414-04-5)

Safety Data

• Hazardous Substances Data: 136414-04-5(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 36304-47-9 1-(2-naphthyloxyacetyl)hydrazine 
• 135-19-3 β-naphthol 
• 6036-14-2 ethyl (naphthalen-2-yloxy)acetate 
• 120-23-0 (2-naphthoyl)oxyacetic acid 

Downstream Products

• 136413-85-9 3-[(3,4-Dichloro-phenylamino)-methyl]-5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 136413-83-7 3-[(3,4-Dimethyl-phenylamino)-methyl]-5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 136413-84-8 3-[1-(3,4-Dimethyl-phenylamino)-ethyl]-5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 139764-61-7 4-{[5-(Naphthalen-2-yloxymethyl)-2-thioxo-[1,3,4]oxadiazol-3-ylmethyl]-amino}-benzoic acid 
• 139764-58-2 3-[(4-Chloro-phenylamino)-methyl]-5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 139764-59-3 3-[(2,4-Dichloro-phenylamino)-methyl]-5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 139764-62-8 3-[(2-Methoxy-phenylamino)-methyl]-5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 

Relevant articles and documents

Synthesis and antimicrobial activity of some 1,3,4-oxadiazole derivatives.

Six new 5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-thione, 2-amino-5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole, 5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-one derivatives have been synthesized from 1-and/or 2-naphthol. The structures of the compounds were confirmed by IR and 1H NMR spectral data and microanalysis. The antimicrobial properties of the compounds were investigated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, Candida albicans, C. krusei and C. parapsilosis using microbroth dilution method. 2-Amino-5-(2-naphthyloxymethyl)-1,3,4-oxadiazole and 5-(2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-one show significantly (32 microg/ml), compounds 5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-thione, 2-amino-5-(1-naphthyloxymethyl)-1,3,4-oxadiazole and 5-(1-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-one moderately (64 microg/ml) active against C. krusei. All the compounds were active against S. aureus, E. coli, P. aeruginosa, C. albicans, and C. parapsilosis at 64-256 microg/ml concentration.

Synthesis and anti tuberculostatic activity of novel 1,3,4-oxadiazole derivatives

A series of novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis H37Rv. The result of the antimycobacterial activity tests revealed that 2-(2-naphthyloxymethyl)-5-phenoxymethyl-1,3,4-oxadiazole (IVd) exhibited > 90% inhibition at MIC ～6.25.

Synthesis and biological properties of Mannich bases of some 5-substituted-1,3,4-oxadiazol-2-thiones

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