1364231-68-4

Upstream product

• 62-53-3 aniline 
• 76464-90-9 N-(2-iodophenylmethyl)aniline 
• 637-44-5 phenylpropyolic acid 
• 26260-02-6 2-iodobenzaldehyde 

Downstream Products

• 1364232-25-6 3-iodo-1-(2-iodobenzyl)-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione 
• 1364232-56-3 6-iodo-5-phenyl-1H-pyrrolo[2,1-e]phenanthridine-2,7-(9H,13bH)-dione 
• 1607433-18-0 1-(2-iodobenzyl)-3-(4-methoxybenzoyl)-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione 
• 913547-39-4 1-(2-iodo-benzyl)-1H-indole-2,3-dione 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Synthesis of 3,4-Fused Tricyclic Indoles through Cascade Carbopalladation and C-H Amination: Development and Total Synthesis of Rucaparib

3,4-Fused tricyclic indole scaffolds are ubiquitous in bioactive natural products and pharmaceuticals. A new protocol for the synthesis of 3,4-fused tricyclic indoles has been developed through cascade carbopalladation and C-H amination with N,N-di-tert-butyldiaziridinone. The protocol allows access to a range of 3,4-fused tricyclic indoles, including those containing various linkers and fused with medium-sized rings. Rucaparib can be synthesized via this reaction, providing an advantageous synthetic method for the FDA-approved cancer medicine.