1364369-16-3

Upstream product

• 4897-84-1 Methyl 4-bromobutyrate 
• 108-46-3 recorcinol 

Downstream Products

• 1364369-21-0 tert-butyl 2-(2-(4-(3-(7-(diethylamino)-2-oxo-2H-chromene-3-carboxamido)propylamino)-4-oxobutoxy)-4-hydroxyphenylazo)benzoate 
• 1364369-10-7 2-((2-(4-(3-(7-(diethylamino)-2-oxo-2H-chromene-3-carboxamido)propylamino)-4-oxobutoxy)-4-hydroxyphenyl)diazenyl)benzoic acid 
• 1364369-32-3 C₅₄H₇₈N₆O₁₆ 
• 1364369-34-5 C₅₁H₇₄N₆O₁₆ 
• 1364369-18-5 4-(2-(2-(tert-butoxycarbonyl)phenylazo)-5-hydroxyphenoxy)butanoic acid 

Relevant academic research and scientific papers

BROMODOMAIN INHIBITORS FOR TREATING DISEASE

Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.

A FRET-based probe with a chemically deactivatable quencher

A new concept of a chemically deactivatable quencher is proposed for a FRET-based probe that turns-on its fluorescence by either an enzymatic cleavage or a chemical reagent (sodium dithionite). This concept allowed us to quantify the caspase-3 cleavage activity in solution and to reveal unreacted probes in cell experiments. The Royal Society of Chemistry 2012.