1364488-05-0Relevant academic research and scientific papers
Enantioselective trapping of an α-chiral carbanion of acyclic nitrile by a carbon electrophile
Sasaki, Michiko,Takegawa, Tomo,Ikemoto, Hidaka,Kawahata, Masatoshi,Yamaguchi, Kentaro,Takeda, Kei
supporting information; experimental part, p. 2897 - 2899 (2012/03/27)
An α-chiral nitrile carbanion generated by deprotonation of enantioenriched O-carbamoyl cyanohydrin was trapped in situ with ethyl cyanoformate to give the corresponding ester derivative in 92% yield and 90:10 er, providing the first example of trapping of an α-chiral acyclic nitrile carbanion that has been considered to be very configurationally labile. The Royal Society of Chemistry 2012.
