136452-88-5

Usage

Chemical structure

1,3-Benzenedicarboxamide, N,N'-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-5-[2-(iodomethyl)-5-oxo-1-pyrrolidinyl]is a complex chemical compound with a benzene dicarboxamide core and multiple functional groups.

Iodine content

The molecule contains multiple iodine atoms, which would make it highly opaque to X-rays.

Functional groups

The compound has acetyloxy and pyrrolidinyl functional groups, which may provide solubility and stability in biological systems.

Upstream product

• 148051-05-2 N,N'-Bis<2,3-bis(acetyloxy)propyl>-2,4,6-triiodo-5-<(1-oxo-4-pentenoyl)amino>-1,3-benzenedicarboxamide 
• 76801-94-0 5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide 
• 39716-58-0 pent-4-enoyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 166818-22-0 5-<2-<(Acetyloxy)methyl>-5-oxo-1-pyrrolidinyl>-N,N'-bis(acetyloxy)propyl-2,4,6-triiodo-1,3-benzenedicarboxamide 

Relevant academic research and scientific papers

Nonionic radiographic contrast agents

New nonionic radiographic contrast agents having the formula STR1 wherein Y is a single bond, --CH2 CH2 --, --CH2 O--, --OCH2 --, STR2 --CH2 --, --CH2 --CH2 --CH2 --,

Heterocyclic Nonionic X-ray Contrast Agents. 4. The Synthesis of Dihydro-2(3H)-furanylidenamino, 5-Oxo-1-pyrrolidinyl, and 5-Oxo-4-morpholinyl Derivatives by an Intramolecular Iodocyclization Approach

Intramolecular iodocyclization of ω-alkenylanilides 6 and anilides 7 resulted in the formation of dihydro-2(3H)-furanylidenamines 8 and 1,4-dioxan-2-ylideneamines 9, respectively, by an amide-oxygen participative nucleophilic attack on the expected iodonium intermediate.The latter heterocyclic ring system is new.If a strong base is present, the mode of ring closure was mainly diverted to an amide-nitrogen participative nucleophilic attack, leading to (iodomethyl)pyrrolidinones 10 and (iodomethyl)morpholinones 11, from 6 and 7, respectively.Unique interconvertible syn-anti isomerism in the imino-ether 8a was demonstrated by variable temperature NMR studies.The major component in this mixture was the 8a-anti-isomer.Acetolysis of the iodocyclized products, followed by deacetylation, provided the heterocyclically substituted polyhydroxytriiodoisophthalamides 16-18.Hydrolytic studies on the imidate 16d revealed an interesting pH dependence.As expected the amine 3d and the amide 22 resulted in pH values of 2 and 6.At pH 12, however, the Chapman rearrangement product 17d was the major product.The compounds obtained in this investigation are of interest as X-ray contrast agents.