136452-99-8

Basic information

• Product Name: 1,3-Benzenedicarboxamide, N,N'-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-5-isocyanato-
• CAS NO: 136452-99-8
• Molecular Formula: C23H24I3N3O11
• Molecular Weight: 899.171
• Mol File: 136452-99-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenedicarboxamide, N,N'-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-5-isocyanato-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenedicarboxamide, N,N'-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-5-isocyanato-(136452-99-8)
• EPA Substance Registry System: 1,3-Benzenedicarboxamide, N,N'-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-5-isocyanato-(136452-99-8)

Safety Data

• Hazardous Substances Data: 136452-99-8(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 76801-94-0 5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide 
• 76801-93-9 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide 
• 99-31-0 5-aminoisophthalic acid 
• 35453-19-1 2,4,6-triiodo-5-aminoisophthalic acid 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 

Downstream Products

• 136453-01-5 N,N'-bis<2,3-bis(acetyloxy)propyl>-5-<4-(hydroxymethyl)-2-oxo-3-oxazolidinyl>-2,4,6-triiodo-1,3-benzenedicarboxamide 

Relevant articles and documents

CONTRAST AGENTS AND DIAGNOSTIC COMPOSITIONS BASED ON IODINE-CONTAINING CYANURIC ACID DERIVATIVES

The present invention relates to a class of compounds of Formula (I) and to diagno stic compositions containing such compounds where the compounds are iodine conta ining compounds. More specifically the iodine containing compounds are chemical compounds containing a cyanuric acid scaffolding moiety allowing for the arrange ment of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imag ing and in particular in X-ray imaging and to contrast media containing such com pounds .

Heterocyclic Nonionic X-ray Contrast Agents. 3. The Synthesis of 5--2,4,6-triiodo-1,3-benzenedicarboxamide Derivatives

The syntheses of 2,4,6-triiodo-1,3-benzenedicarboxamide analogs, 12c, 12e, and 17c, of interest as X-ray diagnostic agents and in which the 5 position is linked to the N atom of a 4-(hydroxymethyl)-oxazolidin-2-one moiety, are described.The heterocycle was built from suitably protected 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid derivatives by a three-step procedure consisting of (1) phosgene treatment to obtain the corresponding isocyanates, (2) phenylmercuric chloride-catalyzed addition of glycidol (10) resulting in glycidil carbamates, and (3) pyridine-catalyzed intramolecular N-alkylation, followed by deprotection, to obtain the oxazolidin-2-ones.The intramolecular N-alkylation reaction was highly regioselective and was not appreciably accompanied by O-alkylation products under the experimental conditions employed.The two carboxamide nitrogen atoms in the intermediates and end products carry either 2,3-dihydroxypropyl or 1,3-dihydroxypropyl residues.These highly congested benzenoid compounds exhibited interesting NMR spectral features due to atropisomerism arising from hindrance to free rotation about the three single bonds that link the aromatic moiety to the N-containing functionalities.