136459-36-4

Upstream product

• 65095-13-8 1-benzotriazolecarboxylic acid chloride 
• 875-74-1 (R)-phenylglycine 
• 856422-37-2 (R)-[(Benzotriazole-1-carbonyl)-amino]-phenyl-acetic acid 

Downstream Products

• 845786-73-4 N-(1-benzotriazolecarbonyl)-D-phenylglycine piperidineamide 
• 845786-75-6 N-(1-benzotriazolecarbonyl)-D-phenylglycine cyclopentylamide 
• 845786-72-3 N-(1-benzotriazolecarbonyl)-D-phenylglycine cyclohexanemethylamide 
• 1248783-34-7 1-((5-hydroxypentylcarbamoyl)(phenyl)methyl)-3-(5-hydroxypentyl)urea 
• 1248783-32-5 1-((2-hydroxyethylcarbamoyl)(phenyl)methyl)-3-(2-hydroxyethyl)urea 
• 1248783-33-6 1-((3-hydroxypropylcarbamoyl)(phenyl)methyl)-3-(3-hydroxypropyl)urea 
• 845786-74-5 N-(1-benzotriazolecarbonyl)-D-phenylglycine diphenylmethylamide 
• 845786-71-2 N-(1-benzotriazolecarbonyl)-D-phenylglycine cyclohexylamide 

Relevant academic research and scientific papers

Novel ureidoamides derived from amino acids: Synthesis and preliminary biological screening

A series of novel amino acid ureidoamides 4a-o were prepared from N-(1-benzotriazolecarbonyl)-amino acid chloride 3, derived from L-alanine, L-valine, L-leucine, D-phenylglycine and L-phenylalanine, and the corresponding aminoalcohols (2-amino-1-ethanol, 3-amino-1-propanol and 5-amino-1-pentanol). The compounds were fully characterized by standard spectroscopic methods (IR, 1H and 13C NMR) and their structure was confirmed by elemental analysis. Antioxidant screenings (interaction with 1,1-diphenyl-2-picrylhydrazyl, soybean lipoxygenase inhibition activity, inhibition of linoleic acid lipid peroxidation) revealed that the prepared compounds possessed only modest activity. On the other hand, no significant antiproliferative activity against five human cell lines and very weak antimicrobial activity against several bacteria and fungi were detected.

The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: Synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations

The novel L- and D-amino acid derivatives of hydroxyurea 5a-o were prepared by aminolysis of N-(1-benzotriazolecarbonyl)amino acid amides 4a-o with hydroxylamine. The hydantoin derivatives 6a-e,m,p were synthesized by base-catalyzed cyclization of amides