136465-99-1

Basic information

• Product Name: QUINALDIC ACID SUCCINIMIDE ESTER
• Synonyms: QUINALDIC ACID SUCCINIMIDE ESTER;N-(2-QUINOLYLCARBONYLOXY) SUCCINIMIDE;1-((2-quinolinyl-carbonyl)oxy)-2,5-pyrrolidinedione
• CAS NO: 136465-99-1
• Molecular Formula: C₁₄H₁₀N₂O₄
• Molecular Weight: 270.24
• EINECS: 418-630-3
• Mol File: 136465-99-1.mol

Chemical Properties

• Melting Point: 190-192 °C(Solv: ethanol (64-17-5))
• Boiling Point: 453.2°Cat760mmHg
• Flash Point: 227.9°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.676
• PKA: -0.18±0.48(Predicted)
• CAS DataBase Reference: QUINALDIC ACID SUCCINIMIDE ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: QUINALDIC ACID SUCCINIMIDE ESTER(136465-99-1)
• EPA Substance Registry System: QUINALDIC ACID SUCCINIMIDE ESTER(136465-99-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41-43
• Safety Statements: 24-26-37/39
• Hazardous Substances Data: 136465-99-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H10N2O4/c17-12-7-8-13(18)16(12)20-14(19)11-6-5-9-3-1-2-4-10(9)15-11/h1-6H,7-8H2

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 93-10-7 quinoline-2-carboxylic acid 

Downstream Products

• 143224-34-4 (S)-N¹-[(1S,2S)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-2-[(quinoline-2-carbonyl)-amino]-succinamide 
• 143224-34-4 Telinavir 
• 136465-98-0 (2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid 
• 127779-20-8 Saquinavir 
• 143224-34-4 [1S-[1R*(R*),2S*]]-N₁[3-[[[(1,1-dimethylethyl)amino]carbonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide 
• 146572-44-3 2(S)-[3(S)-[[N-(2-quinolylcarbonyl)-L-asparaginyl]amino]-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-1(R)-cyclohexanecarboxamide 
• 115732-19-9 (R)-3-Phenyl-2-[(quinoline-2-carbonyl)-amino]-propionic acid 

Relevant articles and documents

Expanding the scope of the elpaN-type library: Glucose-derived bis(pyridine-2-carboxamide) ligands (elpaN-Py) for molybdenum-catalyzed asymmetric allylic alkylations

The elpaN-Py family of ligands, which represents a subset of the elpaN-type library based on d-glucose, is described. The ligands are structural analogs of the privileged bis(pyridine-2-carboxamides) derived from trans-1,2- diaminocyclohexane, and differ

One-pot formation of succinimidyl esters by the system chlorophosphate/hydroxysuccinimide/base

Succinimidyl esters of various carboxylic acids are formed in high yield at ambient to slightly elevated temperature by the system chlorophosphate/hydroxysuccinimide/base.

Synthesis of the HIV-proteinase inhibitor Saquinavir: A challenge for process research

The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir (1), a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield.

N-Acylphenylalanines and Related Compounds. A New Class of Oral Hypoglycemic Agents

N-Benzoyl-DL-phenylalanine (1) was found to possess hypoglycemic activity.A series of the analogues of compound 1 were prepared and evaluated for their blood glucose lowering activity.Both the steric effects of the phenylalanine moiety and the effects of variations in the acyl moiety were investigated.This study elucidated some of the structure-activity relationships and led to the development of N-(4-ethylbenzoyl)-D-phenylalanine (34), which was 50 times more potent than the initial compound 1.