136468-19-4

Usage

Uses

Used in Pharmaceutical Applications:
5-METHOXY-6-METHYL-2-AMINOINDAN is used as a compound with potential pharmaceutical properties due to its activity in the central nervous system. Its investigation for psychoactive drug development is driven by its structural similarity to other psychoactive compounds.
Used in Medicinal Chemistry and Drug Design:
In the field of medicinal chemistry and drug design, 5-METHOXY-6-METHYL-2-AMINOINDAN is utilized for its potential to contribute to the development of new drugs and therapeutic agents. Its unique structure and properties make it a candidate for further exploration and research in creating novel pharmaceuticals.

Upstream product

• 132980-21-3 2-(hydroxyimino)-5-methoxy-6-methyl-1-indanone 
• 24973-22-6 3-methoxy-4-methylbenzaldehyde 
• 67199-60-4 3-(3-methoxy-4-methylphenyl)propanoic acid 
• 67199-56-8 5-methoxy-6-methyl-1-indanone 
• 1685-77-4 6-Methoxy-5-methyl-indan-1-on 
• 28596-61-4 2-Brom-5-methyl-6-methoxyindan-1-on 
• 132980-20-2 3-(3-Methoxy-4-methylphenyl)-2-propenoic acid 

Relevant academic research and scientific papers

Synthesis method of 2-aminoindane derivative and product of 2-aminoindane derivative

The invention provides a synthesis method of a 2-aminoindane derivative. According to the method, 5,6disubstituted 1-indanone is used as a staring raw material; bromination reaction is firstly performed; then, Gabriel reaction is performed; next, hydrazine hydrate is added; hydrolysis reaction is performed, and meanwhile, hydrazone is generated; finally, strong alkali is added into a high-boiling-point solvent to perform heating hydrolysis; the target product of the 2-aminoindane derivative is prepared. The invention also provides the 2-aminoindane derivative prepared by the synthesis method. Compared with the synthesis method of the 2-aminoindane derivative in the prior art, the synthesis method provided by the invention has the advantages that the reaction raw materials are cheap; the reaction condition is mild; the reaction steps are simple; the operation is easy; the yield of the obtained product is higher; the synthesis method is suitable for industrial production. Therefore good application prospects and market potentials are realized.

Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: Similarities to 3,4-(methylenedioxy)methamphetamine (MDMA)

The racemate and the enantiomers of 1-(3-methoxy-4-methylphenyl)-2-aminopropane (6) and racemic 5-methoxy-6-methyl-2-aminoindan (11) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Both 6 and 11 were found to substit