136476-19-2Relevant academic research and scientific papers
Palladium-catalyzed Suzuki–Miyaura reaction of fluorinated vinyl chloride: a new approach for synthesis α and α,β-trifluoromethylstyrenes
Li, Yang,Zhao, Bo,Dai, Kun,Tu, Dong-Huai,Wang, Bo,Wang, Yao-Yu,Liu, Zhao-Tie,Liu, Zhong-Wen,Lu, Jian
, p. 5684 - 5690 (2016/08/23)
A mild and efficient palladium-catalyzed cross-coupling between fluorinated vinyl chloride and arylboronic acids is described. The use of ligand B successfully overcomes the strong electronic withdrawing of trifluoromethylated substrates and allows the efficient synthesis of a wide range of α and α,β-trifluoromethyl containing olefins. By using this method, the key intermediate for synthesis of Efavirenz can be obtained in a simple route. The efficient conversion of two freon molecules into useful α and α,β-trifluoromethyl containing olefins is a useful route in organic chemistry.
