1364791-77-4Relevant articles and documents
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold
Lolli, Marco L.,Giorgis, Marta,Tosco, Paolo,Foti, Antonio,Fruttero, Roberta,Gasco, Alberto
experimental part, p. 102 - 109 (2012/04/04)
Based on some structural analogies with leflunomide and brequinar, two well-known inhibitors of dihydroorotate dehydrogenase (DHODH), a new series of products was designed, by joining the substituted biphenyl moiety to the 4-hydroxy-1,2,5-oxadiazol-3-yl s