397-28-4

Basic information

• Product Name: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE
• Synonyms: AKOS BAR-0142;3'-TRIFLUOROMETHYLBIPHENYL-4-YLAMINE;3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE;3TRIFLUOROMETHYL4AMINOBIPHENYL;4-[3-(Trifluoromethyl)phenyl]aniline
• CAS NO: 397-28-4
• Molecular Formula: C₁₃H₁₀F₃N
• Molecular Weight: 237.22
• Mol File: 397-28-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE(397-28-4)
• EPA Substance Registry System: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE(397-28-4)

Safety Data

• Hazardous Substances Data: 397-28-4(Hazardous Substances Data)

Usage

General Description

3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE is a chemical compound with the molecular formula C13H10F3N. It is a trifluoromethyl-substituted 1,1'-biphenyl-4-amine, which is used in organic synthesis and pharmaceutical research. 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE is known for its unique structure and its potential applications in medicinal and material chemistry. It has also been studied for its biological activity and potential therapeutic uses. As a trifluoromethylated derivative, it is particularly interesting for its potential to modify the physical and chemical properties of various compounds for specific applications.

Upstream product

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Downstream Products

• 1266338-75-3 N-(3-(N-(phenylsulfonyl)phenylsufonamido)-3'-(trifluoromethyl)biphenyl-4-yl)acetamide 
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• 1360630-44-9 6-methoxy-N-(3'-(trifluoromethyl)biphenyl-4-yl)-2-naphthamide 
• 1360630-57-4 6-methoxy-N-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2-sulfonamide 
• 1364791-77-4 4-benzyloxy-N-[3'-(trifluoromethyl)biphenyl-4-yl]-1,2,5-oxadiazole-3-carboxamide 
• 1025913-54-5 [3-(3-cyano-phenyl)-5-(3'-trifluoromethyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester 
• 454-92-2 3-(trifluoromethyl)benzoic acid 

Relevant articles and documents

Base-Promoted Aerobic Oxidation/Homolytic Aromatic Substitution Cascade toward the Synthesis of Phenanthridines

The current protocol represents a transition metal-free synthesis of polysubstituted phenanthridines from abundant starting materials like benzhydrol and 2-iodoaniline derivatives. The reaction involves sequential oxidation of alcohol and direct condensation reaction with the amine resulting in a C?N bond formation followed by a radical C?C coupling in a cascade sequence. The used base potassium tert-butoxide plays a dual role in dehydrogenation and homolytic aromatic substitution reaction. Using this methodology, twenty substituted phenanthridine derivatives were synthesized with up to 85% isolated yield. (Figure presented.).

A terphenyl structure containing between the diamine compound and its synthetic method and application

The invention discloses a diamine compound with a meta-terphenyl structure as well as a synthetic method and application thereof. An amino group is introduced by using an aryl halide through Suzuki reaction, and the functional diamine compound with the meta-terphenyl structure is obtained by virtue of bromination, diazotization, Suzuki coupling and reduction. The synthetic method for the diamine compound is simple and relatively high in yield, and the synthesized compound has certain fluorescence property. The diamine compound can be used for synthesizing high-performance and functional polymers such as polyamide, polyimide, polyamideimide and polyesterimide, and is especially suitable for preparing a soluble, colorless and transparent high-performance functional polyimide material with certain fluorescence property.

I -PrI acceleration of Negishi cross-coupling reactions

(Figure presented) The Negishi cross-coupling of arylzinc reagents with various bromoanilines is accelerated by the presence of i-PrI (1 equiv) and furnished the expected biaryls within 5-12 min reaction time at 25 °C. Arylzinc reagents can also be cross-coupled under these conditions with a range of aryl bromides bearing an enolizable ester or acidic benzylic protons.