136489-59-3Relevant academic research and scientific papers
Diazines. 13. Metalation without Ortho-Directing Group Functionalization of Diazines via Direct Metalation
Ple, Nelly,Turck, Alain,Couture, Karine,Queguiner, Guy
, p. 3781 - 3786 (2007/10/02)
The successful metalation of diazines without an ortho-directing group is described.In some cases, dimers were obtained.The metalation was optimal with LTMP if a 4-fold excess of metalating agent was used, with a very short metalation reaction time at -75
Telesubstitution and Dismutation Reactions in the Series of Phenyl-3-pyridazinylmethane Derivatives
Heinisch, Gottfried,Huber, Thierry
, p. 19 - 22 (2007/10/02)
Reactions of 3-α-chlorobenzylpyridazine (4) with alkoxides have been found to yield 6-substituted or 4-substituted 3-benzylpyridazines (7a-c, 8a-c) rather than the usual ethers (6a-c).Introduction of an electron-donating substituent into the 6-position of the pyridazine nucleus of 4 has been shown to suppress such telesubstitution processes.With phenyl-3-pyridazinylmethanol (3), thermally induced dismutation affording 3-benzylpyridazine (17) and 3-benzoylpyridazine (11) has been observed. Key Words: 3-Pyridazinylmethyl chlorides, reactions with O-nucleophiles / Telesubstitution / Dismutation, thermally induced
