136498-15-2

Usage

Thiazole ring

A ring containing sulfur and nitrogen atoms

Pyrimidine ring

A ring containing nitrogen atoms

Carbonitrile group

A functional group containing a carbon atom triple-bonded to a nitrogen atom

Amino group

A functional group containing a nitrogen atom bonded to hydrogen atoms

4-chlorophenyl substituent

A phenyl group with a chlorine atom attached at the 4-position

Potential biological and medicinal applications

Due to its structure and potential interactions with biological targets

Valuable building block

The compound's synthesis and properties make it useful for developing new pharmaceuticals and agrochemicals

Candidate for new materials

Due to its structural features, it could be used for developing materials with specific electronic or optical properties.

Upstream product

• 1779-81-3 4,5-Dihydro-thiazol-2-ylamin 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

New thiazolopyrimidine derivatives, synthesis and structure-activity relationships

Twenty-six derivatives of 5- and 7-oxo or 5- and 7-aminothiazolopyrimidines were prepared and evaluated as positive inotropic, anti-inflammatory and antihypertensive agents both in vitro and in vivo.The structures of the 5- and 7-isomers have been confirmed unambiguously by IR, UV, 1H and 13C NMR and MS.The structure of 1a was confirmed by the synthesis of compound 1 whose structure had been previously established by X-ray analysis.The 5-aminothiazolo-pyrimidine-6-carbonitrile derivatives 5a and 5e exhibited potent inotropic activities. 5e was more potent thanthe classical reference amrinone.Three compounds 5e, 5i and 5j displayed moderate antihypertensive activities.The 4-chlorophenyl derivative 5d exhibited an anti-inflammatory activity 2-fold that of aspirin.This study has demonstrated that thiazolopyrimidine compounds have interesting biological potentialities, particularly as inotropic agents, a field which had never been explored so far for this series. thiazolopyrimidines / cardiotonic / inotropic / antihypertensive / anti-inflammatory activity

One-pot synthesis of thiazolidino [3,2-a] pyrimidine derivatives

Reaction of 2-aminothiazoline with an aromatic aldehyde and an activated methylene group (malonitrile, diethylmalonate or ethylcyanoacetate) gave the title compounds. The structures are unambiguously assigned using spectroscopic data and chemical proofs.