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Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-2-thiazoline is used as a radiation protectant for its ability to shield biological systems from the harmful effects of radiation. This application is particularly relevant in the pharmaceutical industry, where it can be utilized to protect patients undergoing radiation therapy or to safeguard medical professionals working with radioactive materials.
Used in Chemical Industry:
In the chemical industry, 2-Amino-2-thiazoline can be employed as an intermediate in the synthesis of various compounds, taking advantage of its unique chemical properties. Its versatility as a building block can lead to the development of new materials and products with specific applications in different sectors.
Used in Research and Development:
2-Amino-2-thiazoline's unique structure and properties make it an interesting candidate for research and development purposes. Scientists and researchers can explore its potential in various fields, such as drug discovery, material science, and chemical engineering, to create innovative solutions and advancements.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 5667, 1957 DOI: 10.1021/ja01578a022

InChI:InChI=1/C3H6N2S.H2O4S/c4-3-5-1-2-6-3;1-5(2,3)4/h1-2H2,(H2,4,5);(H2,1,2,3,4)/p-2

Upstream product

• 51-85-4 2,2'-dithio-bis[ethylamine] 
• 151-50-8 potassium cyanide 
• 870-24-6 2-chloroethanamine hydrochloride 
• 333-20-0 potassium thioacyanate 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 56-10-0 S-(2-aminoethyl)isothiouronium bromide hydrobromide 
• 60-23-1 Cysteamine 
• 1147550-11-5 ammonium thiocyanate 
• 6099-88-3 2-Chloroethyl isothiocyanate 
• 1190-74-5 N-(2-mercaptoethyl)guanidine 
• 19767-44-3 1-(2-mercaptoethyl)guanidine hydrochloride 
• 151-16-6 S-(2-aminoethyl)isothiourea 
• 7732-18-5 water 
• 132607-11-5 3-(3-(2-mercaptoethyl)guanidino)propanol 

Downstream Products

• 93323-75-2 3-benzoyl-2-benzoylimino-thiazolidine 
• 664371-61-3 N-acetyl-sulfanilic acid-[3-(N-acetyl-sulfanilyl)-thiazolidin-2-ylidenamide] 
• 55420-40-1 cis-5-(3-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole-6-carboxylic acid ethyl ester 
• 55420-40-1 trans-5-(3-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole-6-carboxylic acid ethyl ester 
• 53750-92-8 6-(2-hydroxy-ethyl)-5-methyl-2,3-dihydro-thiazolo[3,2-a]pyrimidin-7-one 
• 30297-28-0 7-hydroxy-5,7-diphenyl-5H-2,3,6,7-tetrahydrothiazolo[2,3-a]pyrimidine 
• 52780-04-8 N-(4,5-dihydro-thiazol-2-yl)-2-[4-(thiophene-2-carbonyl)-phenyl]-propionamide 
• 14033-37-5 1-(4,5-dihydro-thiazol-2-yl)-3-phenyl-urea 
• 72211-55-3 2,3-dihydrothiazolo<3,2-a>pyrimidine-5,7-dione 
• 30204-45-6 7-hydroxy-7-methyl-5-phenyl-5H-2,3,6,7-tetrahydrothiazolo[2,3-a]pyrimidine 
• 55420-34-3 trans-5-phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole-6-carboxylic acid ethyl ester 
• 55420-34-3 cis-5-phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole-6-carboxylic acid ethyl ester 
• 104742-40-7 1-(4,5-dihydro-thiazol-2-yl)-3-(4-methyl-benzyl)-thiourea 
• 104743-07-9 1-(4,5-dihydro-thiazol-2-yl)-3-(3-methyl-benzyl)-thiourea 

Relevant academic research and scientific papers

Tebipenem pivoxil intermediate and synthesis method and application thereof

The invention belongs to the technical field of medicine, and particularly relates to a tebipenem pivoxil intermediate and a synthesis method and application thereof. The synthesis method comprises the following steps: with ethylamine and chloroacetamide

Easy access to thiazolines and thiazines via tandem S-alkylation- cyclodeamination of thioamides/haloamines

This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.

Solvolysis of 2-amino-2-thiazoline derivatives by aliphatic amino alcohols

The opening of the thiazoline ring upon the action of amino alcohols was studied. The effects of the reagent ratio and structures of the heterocycles and amino alcohols on aminolysis were investigated. A new method was developed for the preparative synthesis of a series of N′-(hydroxyalkyl)-2-guanidinoalkanethiols.

INTRAMOLECULAR CYCLIZATION OF GUANIDINOALKANETHIOLS IN AQUEOUS SOLUTION

We have demonstrated the basic possibility of cyclizing guanidinoalkanethiols of different structure to thiazolines and thiazines.The rate of reaction depends on the pH of the medium.The concentration of buffer and the addition of heavy water and α-D,L-alanine have virtually no effect on the rate of reaction.

Chemistry of Thiazole, I. Synthesis and Properties of 2,3,5,6-Tetrahydro-6-(3-methyl-benzofuran-2-yl)imidazothiazole

Die Titelverbindung 13 wird auf zwei Wegen ausgehend von 2-Hydroxyacetophenon (1) ueber das Benzofuran-Derivat 7 und die Thiazolidine 9 bzw. 10 erhalten.