136498-23-2

Upstream product

• 1779-81-3 4,5-Dihydro-thiazol-2-ylamin 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

New thiazolopyrimidine derivatives, synthesis and structure-activity relationships

Twenty-six derivatives of 5- and 7-oxo or 5- and 7-aminothiazolopyrimidines were prepared and evaluated as positive inotropic, anti-inflammatory and antihypertensive agents both in vitro and in vivo.The structures of the 5- and 7-isomers have been confirmed unambiguously by IR, UV, 1H and 13C NMR and MS.The structure of 1a was confirmed by the synthesis of compound 1 whose structure had been previously established by X-ray analysis.The 5-aminothiazolo-pyrimidine-6-carbonitrile derivatives 5a and 5e exhibited potent inotropic activities. 5e was more potent thanthe classical reference amrinone.Three compounds 5e, 5i and 5j displayed moderate antihypertensive activities.The 4-chlorophenyl derivative 5d exhibited an anti-inflammatory activity 2-fold that of aspirin.This study has demonstrated that thiazolopyrimidine compounds have interesting biological potentialities, particularly as inotropic agents, a field which had never been explored so far for this series. thiazolopyrimidines / cardiotonic / inotropic / antihypertensive / anti-inflammatory activity

One-pot synthesis of thiazolidino [3,2-a] pyrimidine derivatives

Reaction of 2-aminothiazoline with an aromatic aldehyde and an activated methylene group (malonitrile, diethylmalonate or ethylcyanoacetate) gave the title compounds. The structures are unambiguously assigned using spectroscopic data and chemical proofs.