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Usage

Uses

Used in Pharmaceutical Synthesis:
Chalcone is utilized as an intermediate in the synthesis of various pharmaceuticals and natural products. Its chemical structure allows for the creation of a wide range of compounds with diverse therapeutic properties.
Used in Anticancer Applications:
Chalcone serves as an anticancer agent, demonstrating potential in the treatment of various types of cancer. Its anti-inflammatory and antioxidant properties contribute to its effectiveness in combating cancer cells and reducing the associated inflammation.
Used in Anti-inflammatory Applications:
Due to its anti-inflammatory properties, chalcone is used in the development of medications aimed at reducing inflammation and alleviating the symptoms of inflammatory conditions.
Used in Antioxidant Applications:
Chalcone's antioxidant properties make it a useful compound in the development of antioxidants, which are essential in protecting cells from damage caused by free radicals and oxidative stress.
Used in the Biotechnology Industry:
Chalcone's unique chemical structure and pharmacological activities make it a promising candidate for applications in the biotechnology industry, where it can be employed in the development of novel bioactive compounds and therapeutic strategies.

Upstream product

• 92-52-4 biphenyl 
• 92-91-1 biphenyl-4-acetaldehyde 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 1017240-32-2 C₂₁H₁₇ClN₂ 
• 1026350-79-7 4-biphenyl-4-yl-6-(2-chloro-phenyl)-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester 
• 50497-92-2 4,5-dihydro-1-phenyl-3-diphenyl-5-(2-chlorophenyl)-1H-pyrazole 
• 861406-44-2 C₂₅H₂₂ClN₃O 
• 1027026-79-4 3-biphenyl-4-yl-5-(2-chloro-phenyl)-cyclohex-2-enone 

Relevant academic research and scientific papers

Synthesis and characterization of 2-phenylpyrazoline derivatives and evaluation of their activities against antimicrobial and breast cancer cell line in vitro and in silico studies

The new series of 2-phenylpyrazoline derivatives (2a-j) were synthesized and evaluated for their antimicrobial, in silico and in vitro anticancer activity was performed by MTT assay using MDA-MB-231 (human breast adenocarcinoma) cell line. The 2-phenylpyr

An efficient synthesis and in vitro antimicrobial screening of 2-cyanoimino-4-aryl-6-(1,1′-biphenyl-4-yl)-3, 4-dihydro-1H-pyrimidines

An efficient synthesis of 2-Cyanoimino-4-aryl-6-(1,1′-biphenyl-4-yl)-3,4-dihydro-1H-pyrimidines from stryl-4-biphenylketones and cyanoguanidine in presence of sodium hydroxide has been described. Cyanoguanidine serves as N-C=N source for the construction of desired cyanoiminopyrimidines. The structural assignments of the titled products were done accordingly to their spectra like Mass, FT-IR, Proton and Carbon-13NMR spectroscopy. The more stable tautomeric form was ascertained using computational frequency analysis. The tested microorganism profile of compounds exhibits significant antimicrobial activity.

Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents

A series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a-h) and 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (3a-h) were synthesized by condensation of chalcones with hydrazine hydrate in solvent system ethanol and DMF. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activity, and were compared with standard drug. Among the compounds studied, compound 2e showed more potent anti-inflammatory and analgesic activity than the standard drug, along with minimum ulcerogenic index.

Synthesis and antibacterial activity of some 5-(4-biphenylyl)-7-aryl[3,4-d] [1,2,3]-benzothiadiazoles

A series of 5-(4-biphenylyl)-7-aryl[3,4-d] [1,2,3]-benzothiadiazoles were synthesized, characterized by IR, NMR and elemental analysis and evaluated for in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that compounds 7a-j had better activity against tested Gram-positive organisms than the reference ciprofloxacin and norfloxacin. However, the compounds were nearly inactive against Gram-negative bacteria. Compound 7c and 7d were the most active compounds against Gram-positive bacteria.

Synthesis and antibacterial activities of some 2-amino-4,6- diarylpyrimidines

A series of 2-aminopyrimidines have been prepared by the condensation of 1-(1,1′-biphenyl-4-yl)-3-arylprop-2-en-1-ones with guanidine-nitrate and characterized on the basis of analytical and spectral data. The compounds have been screened for their antibacterial activities.