1365052-53-4

Upstream product

• 1761-61-1 5-bromosalicyclaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 636992-53-5 1-(3-amino-5-bromo-benzofuran-2-yl)-ethanone 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 

Downstream Products

• 1365052-63-6 C₁₇H₁₃BrFN₃O 

Relevant academic research and scientific papers

Synthesis and biological evaluation of some novel benzofuranpyridine derivatives

5-Bromo-3-amino-2-acetyl benzofuran 3 was prepared by the reaction of 5- bromosalicylonitrile 2 with chloroacetone in dry acetone in presence of anhydrous potassium carbonate to maintain basic condition. The Claisen-Schmidt condensation of compound 3 with various substituted aromatic aldehydes in presence of strong base in absolute ethanol gave 5-bromo-3-amino-2-arylidine acetyl benzofuran 4a-f in good yields. The compounds 4a-f upon treatment with orthophosphoric acid in acetic acid underwent cyclisation and resulted in the formation of above titled compounds 5a-f. All synthesized compounds were characterized on the basis of its physical constant, analytical and spectral studies. Further these compounds were evaluated for their antibacterial and antifungal activities.

Synthesis and antiinflammatory activity of 1H-pyrazolines bearing 5-bromo-3-amino benzofuran

5-Bromo-3-amino-2-acetyl banzofuran 3 was prepared by the interaction of 5-bromosalicylonitrile and chloroacetone in presence of anhyd potassium carbonate in dry acetone. The compound 3 was treated with different substituted aromatic aldehydes in ethanol in presence of strong alkali to give 5-bromo-3-amino-2-arylidene acetylbenzofurans (4a-e). 5-(3-Amino-5- bromobenzofuran)-3-aryl-2-pyrazolines (5ae) were synthesized by the reaction of 5-bromo-3-amino-2-arylidene acetylbenzofurans (4a-e) with hydrazine hydrate. The reaction of compounds (5a-e) with chloroacetyl chloride in presence of triethylamine in dry toluene furnished 5-aryl-3-[5'-bromo-3'-(chloroacetyl)- aminobenzofuran-2-yl]-1H-pyrazolines (6a-e). All synthesized compounds were screened for their antimicrobial activities and some selected benzofuran pyrazoline derivatives were screened for antiinflammatory activities.