636992-53-5

Basic information

• Product Name: Ethanone, 1-(3-amino-5-bromo-2-benzofuranyl)-
• CAS NO: 636992-53-5
• Molecular Formula: C10H8BrNO2
• Molecular Weight: 254.083
• Mol File: 636992-53-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(3-amino-5-bromo-2-benzofuranyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-amino-5-bromo-2-benzofuranyl)-(636992-53-5)
• EPA Substance Registry System: Ethanone, 1-(3-amino-5-bromo-2-benzofuranyl)-(636992-53-5)

Safety Data

• Hazardous Substances Data: 636992-53-5(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(3-amino-5-bromo-2-benzofuranyl)- is a chemical compound that is also known by the trade name Brimonidine. It is commonly used in the treatment of glaucoma, as it works by reducing the amount of fluid in the eye and increasing the flow of fluid out of the eye. It is also used to treat ocular hypertension. Ethanone, 1-(3-amino-5-bromo-2-benzofuranyl)- is known to be effective in lowering intraocular pressure and is often used in eye drops for its therapeutic effects. However, it is important to use this medication as prescribed by a healthcare professional due to potential side effects such as blurred vision, dizziness, and drowsiness.

Upstream product

• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 78-95-5 chloroacetone 
• 1761-61-1 5-bromosalicyclaldehyde 
• 49615-91-0 2-(2-oxopropoxy)benzonitrile 
• 611-20-1 salicylonitrile 
• 295346-39-3 5-bromo-2-(2-oxopropoxy)benzonitrile 

Downstream Products

• 688757-75-7 2-acetyl-5-bromo-3-(3-phenylprop-2-enonyl)aminobenzo[b]furan 
• 803685-70-3 2-acetyl-5-bromo-(E)-3-(4-methoxycinnamoylamino)-benzo[b]furan 
• 1365052-65-8 C₁₇H₁₃Br₂N₃O 
• 1365052-67-0 C₁₉H₁₉BrN₄O 
• 1365052-69-2 C₁₉H₁₅BrClN₃O₂ 
• 1365052-71-6 C₁₉H₁₄BrCl₂N₃O₂ 
• 1365052-74-9 C₁₉H₁₄BrClFN₃O₂ 
• 1365052-76-1 C₁₉H₁₄Br₂ClN₃O₂ 
• 1365052-77-2 C₂₁H₂₀BrClN₄O₂ 
• 1365052-59-0 C₁₇H₁₄BrN₃O 
• 1365052-61-4 C₁₇H₁₃BrClN₃O 
• 1365052-63-6 C₁₇H₁₃BrFN₃O 
• 1365052-49-8 2-cinnamoyl-3-amino-5-bromo-benzofuran 
• 1365052-51-2 C₁₇H₁₁BrClNO₂ 

Relevant articles and documents

HCV PROTEASE INHIBITORS

The present invention discloses a compound of general formula (I); A is O, S, CH, NH or NR', when O links with Z3, Z1 is N or CRZ1, Z2 is CRZ2, when Z1 links with O, Z2 is CH, Z3 is C-Ar; Ra, Rb, Rc and Rd independently is H, OH, halogen or -Y1-Rm; A1 is NH or CH2; R1' is alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl; A2 is N, O or linking bond; R1 is hydrogen, or, R1 linking covalently with R3 forms C5-C9 saturated or unsaturated hydrocarbon chain substituted by O or N; R3 is alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted by cycloalky etc; R4 is alkoxy-CO, alkyl-NHCO, (alkyl)2NCO, or formyl substituted by aryl, cycloalkyl, heterocycloalkyl.

Synthesis and biological evaluation of some novel benzofuranpyridine derivatives

5-Bromo-3-amino-2-acetyl benzofuran 3 was prepared by the reaction of 5- bromosalicylonitrile 2 with chloroacetone in dry acetone in presence of anhydrous potassium carbonate to maintain basic condition. The Claisen-Schmidt condensation of compound 3 with various substituted aromatic aldehydes in presence of strong base in absolute ethanol gave 5-bromo-3-amino-2-arylidine acetyl benzofuran 4a-f in good yields. The compounds 4a-f upon treatment with orthophosphoric acid in acetic acid underwent cyclisation and resulted in the formation of above titled compounds 5a-f. All synthesized compounds were characterized on the basis of its physical constant, analytical and spectral studies. Further these compounds were evaluated for their antibacterial and antifungal activities.

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.