1365059-89-7Relevant academic research and scientific papers
Nature-inspired total synthesis of (-)-fusarisetin A
Xu, Jing,Caro-Diaz, Eduardo J. E.,Trzoss, Lynnie,Theodorakis, Emmanuel A.
, p. 5072 - 5075 (2012)
A concise, protecting group-free total synthesis of (-)-fusarisetin A (1) was efficiently achieved in nine steps from commercially available (S)-(-)-citronellal. The synthetic approach was inspired by our proposed biosynthesis of 1. Key transformations of our strategy include a facile construction of the decalin moiety that is produced via a stereoselective IMDA reaction and a one-pot TEMPO-induced radical cyclization/aminolysis that forms the C ring of 1. Our route is amenable to analogue synthesis for biological evaluation.
