1365110-05-9Relevant academic research and scientific papers
Asymmetric total synthesis of (+)-virosine A via sequential nucleophilic cyclizations onto an activated formamide
Belanger, Guillaume,Dupuis, Marianne,Larouche-Gauthier, Robin
, p. 3215 - 3221 (2012)
The first synthesis of tetracyclic alkaloid virosine A is reported. The natural alkaloid was prepared in only 13 steps, in an enantioenriched form. The azabicyclo[2.2.2]octane core was efficiently assembled using a key Vilsmeier-Haack and Mannich cyclizations sequence performed in one pot.
