1365212-61-8

Basic information

• Product Name: (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine
• Synonyms: (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine
• CAS NO: 1365212-61-8
• Molecular Weight: 361.216
• Mol File: 1365212-61-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine(1365212-61-8)
• EPA Substance Registry System: (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine(1365212-61-8)

Safety Data

• Hazardous Substances Data: 1365212-61-8(Hazardous Substances Data)

Upstream product

• 6775-78-6 6-chloroimidazo[1,2-b]pyridazine 
• 1364890-61-8 (2R)-2-(3-fluorophenyl)pyrrolidine hydrochloride 
• 13526-66-4 3-bromo-6-chloro-imidazo[1,2-b]pyridazine 

Downstream Products

• 1196552-11-0 (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-(2-methyl-1,3-dioxolan-2-yl)pyridine-2-yl)imidazo[1,2-b]pyridazine 
• 1365213-89-3 3-(3-fluorophenyl)-1-{6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl}propan-1-one 
• 1365212-62-9 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile 
• 1365213-30-4 N-(3-cyanophenyl)-6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carboxamide 
• 1365214-06-7 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N-(4-methylpiperazin-1-yl)imidazo[1,2-b]pyridazine-3-carboxamide 
• 1365214-67-0 (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylic acid 
• 1365214-71-6 (R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol 
• 1365214-32-9 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-hydroxyimidazo[1,2-b]pyridazine-3-carboximidamide 
• 1365214-33-0 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-N'-methoxyimidazo[1,2-b]pyridazine-3-carboximidamide 
• 1365214-86-3 (R)-3-(3-fluorophenyl)-1-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)prop-2-en-1-one 
• 1196547-19-9 4-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile 
• 1196550-66-9 (R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone 
• 1196548-56-7 (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine 
• 1196552-12-1 (R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazole[1,2-b]pyridazin-3-yl)pyridine-2-yl)ethanone 

Relevant articles and documents

(R)-2-Phenylpyrrolidine substituted imidazopyridazines: A new class of potent and selective pan-TRK inhibitors

Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have be