1365271-57-3

Basic information

• Product Name: C₃₁H₄₂ClN₇O₅SSi
• Synonyms: C₃₁H₄₂ClN₇O₅SSi
• CAS NO: 1365271-57-3
• Molecular Weight: 688.323
• Mol File: 1365271-57-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₁H₄₂ClN₇O₅SSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₄₂ClN₇O₅SSi(1365271-57-3)
• EPA Substance Registry System: C₃₁H₄₂ClN₇O₅SSi(1365271-57-3)

Safety Data

• Hazardous Substances Data: 1365271-57-3(Hazardous Substances Data)

Upstream product

• 1719-53-5 diethyldichlorosilane 
• 818-61-1 2-hydroxyethyl acrylate 
• 302962-49-8 dasatanib 

Relevant articles and documents

Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles

Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm × 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water-soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and, therefore, the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months.