136533-91-0Relevant academic research and scientific papers
Unique spirocyclopiperazinium salt. Part 2: Synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics
Wang, Xin,Gao, Feng-Li,Piao, Hong-Bin,Cheng, Tie-Ming,Li, Run-Tao
, p. 1729 - 1732 (2003)
Three series of spirocyclopiperazinium derivatives 5a-d, 6a-f and 17a-d were synthesized and evaluated for their in vivo analgesic activities. Compounds 5a, 17a and 17b exhibited excellent analgesic activity. Two important structure-activity relationships were observed from this study: (1) the quaternary ammonium functionality is a critical pharmacophore for analgesic activity; (2) it is important to adjust the lipophilic property of compounds to improve analgesic activity.
GLYCEROL DERIVATIVES AND METHODS OF MAKING SAME
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Page/Page column 45, (2009/01/20)
Symmetrical polyols, polyol esters, polyesters, polyurethanes, triazoles, and polyvinylethers derived from glycerol and methods of making the symmetrical polyols, polyesters, polyurethanes, polyhydroxyvinylethers and triazoles are discussed. Also provided is a method of making serinol.
Glycerol derivatives, and therapeutical compositions containing them
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, (2008/06/13)
The invention relates to glycerol derivatives of general formulae Ia, Ib and Ic STR1 wherein R1, R2, R3, A and Y stand for various substituents, to a preparation process of said compounds and to therapeutical compositions
