136534-64-0Relevant academic research and scientific papers
Two-Step Protocol for Iodotrimethylsilane-Mediated Deoxy-Functionalization of Alcohols
Chen, Yuming,He, Ru,Song, Hongjian,Yu, Guoqing,Li, Chenglin,Liu, Yuxiu,Wang, Qingmin
supporting information, p. 1179 - 1183 (2021/02/01)
We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcohols to afford products containing a C?N, C?S, or C?O bond. In the first step the alcohol undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-molecule drugs containing hydroxy-group.
Structure-activity relationships for a series of bis(phenylalkyl)amines: Potent subtype-selective inhibitors of N-methyl-D-aspartate receptors
Tamiz, Amir P.,Whittemore, Edward R.,Zhou, Zhang-Lin,Huang, Jin-Cheng,Drewe, John A.,Chen, Jie-Cheng,Cai, Sui-Xiong,Weber, Eckard,Woodward, Richard M.,Keana, John F. W.
, p. 3499 - 3506 (2007/10/03)
A series of bis(phenylalkyl)amines, structural analogues of ifenprodil and nylidrin, were synthesized and tested for antagonism of N-methyl-D- aspartate (NMDA) receptors. Potency and subunit selectivity were assayed by electrical recordings in Xenopus ooc
