1365386-49-7

Upstream product

• 4949-45-5 benzyl 2-methylacetoacetate 
• 1224680-15-2 C₁₉H₂₂N₂O*C₁₉H₂₈N₂O₄Si 
• 1224680-16-3 C₂₆H₄₀N₂O₄Si 
• 1224680-14-1 (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid 
• 1224680-13-0 C₁₉H₂₈N₂O₄Si 
• 1224680-12-9 C₂₆H₃₄N₂O₄Si 
• 1224680-11-8 benzyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1224680-17-4 cyclohexylmethyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Downstream Products

• 1224681-54-2 (S)-cyclohexylmethyl 4-(3-(tertbutoxycarbonyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1224681-57-5 (S)-cyclohexylmethyl 4-(3-((S)-2-(tertbutoxycarbonylamino)propanoyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Discovery of 3,4-dihydropyrimidin-2(1H)-ones with inhibitory activity against HIV-1 replication

3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) were selected and derivatized through a HIV-1 replication assay based on GFP reporter cells. Compounds 14, 25, 31, and 36 exhibited significant inhibition of HIV-1 replication with a good safety profile. Chiral separation of each enantiomer by fractional crystallization showed that only the S enantiomer retained anti-HIV activity. Compound (S)-40, a novel and potent DHPM analog, could serve as an advanced lead for further development and the determination of the mechanism of action.

ANTI VIRAL COMPOUNDS

There is provided small molecule anti-human immunodeficiency virus (anti-HIV) compounds as well as a phenotypic cell-based high throughput screening (HTS) assay for their identification.