136540-26-6

Upstream product

• 65967-25-1 5-methyl-2,3,8,9-tetramethoxy-5,6-dihydrobenzophenanthridine 
• 136540-25-5 3-<2-(2-hydroxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-2-methylisoquinolin-1-<2H>-one 
• 125455-89-2 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2-dihydroisoquinoline-1-one 
• 114253-63-3 O-methyl-6-oxofagaronine 

Downstream Products

• 15462-10-9 2,3,8,9-tetramethoxybenzophenanthridine 
• 54785-54-5 O-methylfagaronine chloride 

Relevant academic research and scientific papers

A Simple and Efficient Synthetic Route to Benzophenanthridines

The benzophenanthridine nucleus has been prepared in an overall yield of 52-58percent in five stages.Synthetic route employs as key steps the intramolecular cyclisation of vinyl alcohols followed by a novel one pot double oxidation using iodine in etha

BENZOPHENANTHRIDES. XV. SYNTHESIS OF O-METHYLFAGARONINE IODIDE AND CHLORIDE FROM 13α-HYDROXYXYLOPININE

Hydroborination of 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2-dihydro-1-isoquinolone gave 3--6,7-dimethoxy-2-methylisoquinolin-1-one, which was converted by the action of various oxidizing agents into a benzophenanthridone derivative. 5-Methyl-5,6-dihydro-2,3,8,9-tetramethoxybenzophenanthridine, obtained from the above benzophenanthridone by reduction with LiAlH4 in tetrahydrofuran at 0 deg C, was converted into O-methylfagaronine iodide by boiling in an ethanolic solution of I2 in the presence of Na acetate.On exchanging I- by Cl-, O-methylfagaronine chloride was obtained in a quantitative yield in boiling methanol with an excess of AgCl.