125455-89-2

Basic information

• Product Name: 1(2H)-Isoquinolinone, 3-(2-ethenyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-
• CAS NO: 125455-89-2
• Molecular Formula: C22H23NO5
• Molecular Weight: 381.428
• Mol File: 125455-89-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1(2H)-Isoquinolinone, 3-(2-ethenyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone, 3-(2-ethenyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-(125455-89-2)
• EPA Substance Registry System: 1(2H)-Isoquinolinone, 3-(2-ethenyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-(125455-89-2)

Safety Data

• Hazardous Substances Data: 125455-89-2(Hazardous Substances Data)

Upstream product

• 83527-65-5 (7R^*,13S^*,13aR^*)-(+/-)-7-methyl-13-hydroxy-2,3,10,11-tetramethoxydibenzoquinolizidinium iodide 
• 125516-07-6 α-N-methyl-(+/-)-13α-hydroxyxylopinine p-toluenesulfonate 
• 470461-18-8 (Z)-ethyl 1-(4,5-dimethoxy-2-vinylphenyl)-2-(3,4-dimethoxyphenyl)vinylcarbamate 
• 60315-12-0 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-1,2-dihydroisoquinol-1-one 
• 74-88-4 methyl iodide 
• 136540-25-5 3-<2-(2-hydroxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-2-methylisoquinolin-1-<2H>-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 470461-20-2 [(Z)-2-(3,4-Dimethoxy-phenyl)-1-(4,5-dimethoxy-2-vinyl-phenyl)-vinyl]-methyl-carbamic acid ethyl ester 
• 22185-86-0 ethyl 1-(3',4'-dimethoxybenzylidene)-3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinecarboxylate 

Downstream Products

• 199292-64-3 6,7-dimethoxy-3-[2-(2',2-dimethoxyethyl)-4,5-dimethoxyphenyl]-2-methyl-1(2H)-isoquinolinone 
• 136540-28-8 11-hydroxy-5,11-dimethyl-2,3,8,9-tetramethoxy-11H-indeno<1,2-c>isoquinolone 
• 125455-88-1 5,11-dimethyl-2,3,8,9-tetramethoxy-11H-indeno<1,2-c>isoquinolinium chloride 
• 136540-25-5 3-<2-(2-hydroxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-2-methylisoquinolin-1-<2H>-one 
• 125455-90-5 5,11-dimethyl-2,3,8,9-tetramethoxy-11H-indeno<1,2-c>isoquinolone 
• 114253-63-3 O-methyl-6-oxofagaronine 
• 140169-36-4 3-<2-(2-hydroxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-2-methylisoquinolone O-acetate 
• 136540-26-6 O-methylfagaronine iodide 
• 15462-10-9 2,3,8,9-tetramethoxybenzophenanthridine 

Relevant articles and documents

A new route to 3-(2-vinylphenyl)-2-methyl-2H-isoquinolin-1-ones and benzo[c]phenanthridines: Total synthesis of fagaronine

Treatment of N-carbethoxy-1-benzylideneisoquinolines with LDA gives N-ethoxycarbonyl-1-amino-1-(2-vinylphenyl)-2-phenylethylenes, which can be transformed into 3-(2-vinylphenyl)-2-methyl-2H-isoquinolin-1-ones by Bischler-Napieralski reactions, and thence

BENZOPHENANTHRIDES. XV. SYNTHESIS OF O-METHYLFAGARONINE IODIDE AND CHLORIDE FROM 13α-HYDROXYXYLOPININE

Hydroborination of 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2-dihydro-1-isoquinolone gave 3--6,7-dimethoxy-2-methylisoquinolin-1-one, which was converted by the action of various oxidizing agents into a benzophenanthridone derivative. 5-Methyl-5,6-dihydro-2,3,8,9-tetramethoxybenzophenanthridine, obtained from the above benzophenanthridone by reduction with LiAlH4 in tetrahydrofuran at 0 deg C, was converted into O-methylfagaronine iodide by boiling in an ethanolic solution of I2 in the presence of Na acetate.On exchanging I- by Cl-, O-methylfagaronine chloride was obtained in a quantitative yield in boiling methanol with an excess of AgCl.

BENZOPHENANTHRIDINES. IX. SYNTHESIS OF 11-METHYL-C-NORFAGARONINE METHYL ETHER CHLORIDE FROM (+/-)-13α-HYDROXYXYLOPININE

The previously unknown chloride of 11-methyl-C-norfagaronine methyl ether was synthesized from (+/-)-13α-hydroxyxylopinine in four stages.A reduction in the number of stages in the biometic synthesis of the analog of benzophenanthridine alkaloids was achieved by the Hofmann degradation of α-N-methyl-(+/-)-13α-hydroxyxylopinine p-toluenesulfonate, accompanied by dehydration and oxidation.