1365533-55-6Relevant articles and documents
Asymmetric induction in domino Heck-aza-Michael reactions
Priebbenow, Daniel L.,Stewart, Scott G.,Pfeffer, Frederick M.
, p. 1468 - 1471 (2012/04/10)
Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68-81%) with moderate to high diastereoselectivity (up to 92% de).